Nature Communications (Nov 2020)
Parabrachial nucleus circuit governs neuropathic pain-like behavior
- Li Sun,
- Rui Liu,
- Fang Guo,
- Man-qing Wen,
- Xiao-lin Ma,
- Kai-yuan Li,
- Hao Sun,
- Ceng-lin Xu,
- Yuan-yuan Li,
- Meng-yin Wu,
- Zheng-gang Zhu,
- Xin-jian Li,
- Yan-qin Yu,
- Zhong Chen,
- Xiang-yao Li,
- Shumin Duan
Affiliations
- Li Sun
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Rui Liu
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Fang Guo
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Man-qing Wen
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Xiao-lin Ma
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Kai-yuan Li
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Hao Sun
- Department of Neurology of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine
- Ceng-lin Xu
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Yuan-yuan Li
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Meng-yin Wu
- Department of Epidemiology and Biostatistics, School of Public Health, Zhejiang University
- Zheng-gang Zhu
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Xin-jian Li
- Department of Neurology of the Second Affiliated Hospital, Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine
- Yan-qin Yu
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Zhong Chen
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Xiang-yao Li
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- Shumin Duan
- Department of Neurobiology and Department of Neurology of Second Affiliated Hospital, Zhejiang University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-19767-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 21
Abstract
The parabrachial nucleus (PBN) projects to the amygdala, and contributes to affective aspects of neuropathic pain. Here the authors demonstrate that the lateral parabrachial nucleus (LPBN) contributes to hypersensitivity in a mouse model of neuropathic pain.
