STUDY OF THE EFFECT OF STRUCTURE ON OCTANOL-WATER DISTRIBUTION OF 6-HYDROXYPYRIMIDINE-4-(<i>3H</i>)-ONES DERIVATIVES

Abstract

The results of an experimental study of the effect of structure of substituting groups and pH value on the partition coefficients in biphasic systems of n-octanol and water for a number of 2,5-substituted 6-hydroxypyrimidine-4-(3H)-ones are presented.

Keywords

• pharmaceutical substance
• 6-hydroxypyrimidine-4(3h)-on
• partition coefficient
• absorption
• biopharmacy
• heterocyclic compounds
• ph
• lipophilicity