Evaluation of risk factors of disease progression in HIV-infected patients with relapses of pulmonary tuberculosis

Abstract

There are no defined risk factors for progression of TB in HIV-positive patients with relapses of pulmonary tuberculosis (RTB/HIV) nowadays. In order to identify the risk factors of disease progression 23 patients with RTB/HIV were examined; we determined complex influence of clinical, radiological, immunological and laboratory parameters on the progression of TB. We determined the following risk factors: the presence of systemic inflammatory response syndrome, massive bacterial excretion, multiple destructive process in the lungs, reducing the number of CD4+-cells 2.0 units, decreased lymphocyte level and <18 g/l, albumin level reduction <40%, reduction of albumins/globulins <0.7 units). In this case each "small criterion" we estimate at 1 point. To determine the progressive course minimum number of points (1 out of 5) is necessary.

Keywords

• Tuberculosis
• HIV
• Coinfection
• Risk Factors
• Disease Progression