Integrins are double-edged swords in pulmonary infectious diseases

Ye Yao; Huijun Liu; Lin Yuan; Xizi Du; Yu Yang; Kai Zhou; Xinyu Wu; Ling Qin; Ming Yang; Yang Xiang; Xiangping Qu; Xiaoqun Qin; Chi Liu

Biomedicine & Pharmacotherapy (Sep 2022)

Integrins are double-edged swords in pulmonary infectious diseases

Ye Yao,
Huijun Liu,
Lin Yuan,
Xizi Du,
Yu Yang,
Kai Zhou,
Xinyu Wu,
Ling Qin,
Ming Yang,
Yang Xiang,
Xiangping Qu,
Xiaoqun Qin,
Chi Liu

Affiliations

Ye Yao: Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Huijun Liu: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Lin Yuan: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Xizi Du: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Yu Yang: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Kai Zhou: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Xinyu Wu: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Ling Qin: Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China
Ming Yang: Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, University of Newcastle and Hunter Medical Research Institute, Callaghan, NSW, Australia
Yang Xiang: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Xiangping Qu: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Xiaoqun Qin: Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China
Chi Liu: Department of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Physiology, School of Basic Medicine Science, Central South University, Changsha, Hunan, China; Research Center of China-Africa Infectious Diseases, Xiangya School of Medicine Central South University, Changsha, Hunan, China; Corresponding author at: Department of Physiology, Xiangya School of Medicine, Central South University at Changsha, Hunan 410078, China.

Journal volume & issue: Vol. 153
p. 113300

Abstract

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Integrins are an important family of adhesion molecules that are widely distributed on immune cells in the lungs. Of note, accumulating evidences have shown that integrins are double-edged swords in pulmonary infectious diseases. On one hand, integrins promote the migration of immune cells to remove the invaded pathogens in the infected lungs. However, on the other hand, integrins also act as the targets for pathogens to escape from host immune system, which is a potential factor leading to further tissue damage. Thus, the innovative therapeutic strategies based on integrins has inspired well-founded hopes to treat pulmonary infectious diseases. In this review, we illustrate the involvement of integrins in pulmonary infectious diseases, and further discuss the innovative therapeutic targets based on integrins.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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