Pediatric Health, Medicine and Therapeutics (Jun 2018)
Subacute sclerosing panencephalitis – current perspectives
Abstract
Sidra K Jafri, Raman Kumar, Shahnaz H Ibrahim Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan Abstract: Subacute sclerosing panencephalitis is a progressive neurodegenerative disease. It usually occurs 7–10 years after measles infection. The clinical course is characterized by progressive cognitive decline and behavior changes followed by focal or generalized seizures as well as myoclonus, ataxia, visual disturbance, and later vegetative state, eventually leading to death. It is diagnosed on the basis of Dyken’s criteria. There is no known cure for subacute sclerosing panencephalitis to date, but it is preventable by ensuring that an effective vaccine program for measles is made compulsory for all children younger than 5 years in endemic countries. Keywords: SSPE, progressive, vaccine, preventable
