Journal of Cancer Research and Practice (Mar 2015)

The Outcome of Allogeneic Hematopoietic Stem Cell Transplantation for Myelofibrosis: a Retrospective Study in a Single Center

  • Mei-Fang Hou,
  • Hsin-An Hou,
  • Chien-Ting Lin,
  • Chi-Cheng Li,
  • Ming Yao,
  • Jie-Yang Jhuang,
  • Chung-Wu Lin,
  • Bor-Sheng Ko,
  • Shang-Yi Huang,
  • Wen-Chien Chou,
  • Yao-Chang Chen,
  • Hwei-Fang Tien,
  • Jih-Luh Tang

DOI
https://doi.org/10.6323/JCRP.2015.2.1.04
Journal volume & issue
Vol. 2, no. 1
pp. 31 – 41

Abstract

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Purpose: Nowadays, myelofibrosis can be cured only by allogeneic hematopoietic stem cell transplantation (allo-HSCT), but the transplantation experience is very limited worldwide. We retrospectively investigated the treatment outcome of myelofibrosis patients post allo-HSCT at National Taiwan University Hospital. Results: Eleven myelofibrosis patients received allo-HSCT. The median age at transplantation was 51 years old and the median time from diagnosis to transplantation was 10.1 months. All patients were classified as intermediate-2 or high risk based on the International Prognostic Scoring System (IPSS). Conditioning regimens were myeloablative in 5 and reduced-intensity in 6 patients. All patients achieved full donor chimerism, and post-transplantation bone marrow biopsies showed significant improvement of myelofibrosis in 3 patients. The transplant-related mortality at 100 days post transplantation was 9%. Four patients had grade III-IV acute graft-versus-host disease. Six patients died, and the causes of death were GVHD (n=3), infection (n=2) and secondary graft failure (n=1). The estimated overall survival at two years was 45.5%. Conclusions: Allogeneic hematopoietic stem cell transplantation is effective in treating myelofibrosis and is associated with modest toxicity and post-transplantation complications. In order to improve the treatment outcome, we have to manage GVHD and infection more carefully.

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