Communications Biology (Apr 2022)
Excess S-adenosylmethionine inhibits methylation via catabolism to adenine
Abstract
S-adenosylmethionine (SAM) is a widely available dietary supplement. Exogenous SAM is catabolized to adenine, an inhibitor of adenosylhomocysteinase, leading to widespread methylation inhibition and disruption of circadian rhythms in vitro and in mice.