Communications Biology (Apr 2022)

Excess S-adenosylmethionine inhibits methylation via catabolism to adenine

  • Kazuki Fukumoto,
  • Kakeru Ito,
  • Benjamin Saer,
  • George Taylor,
  • Shiqi Ye,
  • Mayu Yamano,
  • Yuki Toriba,
  • Andrew Hayes,
  • Hitoshi Okamura,
  • Jean-Michel Fustin

DOI
https://doi.org/10.1038/s42003-022-03280-5
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 15

Abstract

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S-adenosylmethionine (SAM) is a widely available dietary supplement. Exogenous SAM is catabolized to adenine, an inhibitor of adenosylhomocysteinase, leading to widespread methylation inhibition and disruption of circadian rhythms in vitro and in mice.