Dual mechanism β-amino acid polymers promoting cell adhesion

Qi Chen; Donghui Zhang; Wenjing Zhang; Haodong Zhang; Jingcheng Zou; Mingjiao Chen; Jin Li; Yuan Yuan; Runhui Liu

doi:10.1038/s41467-020-20858-x

Nature Communications (Jan 2021)

Dual mechanism β-amino acid polymers promoting cell adhesion

Qi Chen,
Donghui Zhang,
Wenjing Zhang,
Haodong Zhang,
Jingcheng Zou,
Mingjiao Chen,
Jin Li,
Yuan Yuan,
Runhui Liu

Affiliations

Qi Chen: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology
Donghui Zhang: Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Wenjing Zhang: Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Haodong Zhang: Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Jingcheng Zou: Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Mingjiao Chen: Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Jin Li: Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine
Yuan Yuan: Key Laboratory for Ultrafine Materials of Ministry of Education, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology
Runhui Liu: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology

DOI: https://doi.org/10.1038/s41467-020-20858-x
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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Cell adhesion peptides like RGD are important to biomedical applications but suffer from proteolysis as well as processing and cost issues. Here, the authors report on the development of cationic-hydrophobic amphiphilic β-amino acid polymers which function as cell adhesion motifs but are resistant to proteolysis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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