Nature Communications (Mar 2022)
Multi-modal profiling of human fetal liver hematopoietic stem cells reveals the molecular signature of engraftment
- Kim Vanuytsel,
- Carlos Villacorta-Martin,
- Jonathan Lindstrom-Vautrin,
- Zhe Wang,
- Wilfredo F. Garcia-Beltran,
- Vladimir Vrbanac,
- Dylan Parsons,
- Evan C. Lam,
- Taylor M. Matte,
- Todd W. Dowrey,
- Sara S. Kumar,
- Mengze Li,
- Feiya Wang,
- Anthony K. Yeung,
- Gustavo Mostoslavsky,
- Ruben Dries,
- Joshua D. Campbell,
- Anna C. Belkina,
- Alejandro B. Balazs,
- George J. Murphy
Affiliations
- Kim Vanuytsel
- Section of Hematology and Medical Oncology, School of Medicine, Boston University
- Carlos Villacorta-Martin
- Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center
- Jonathan Lindstrom-Vautrin
- Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center
- Zhe Wang
- Division of Computational Biomedicine, School of Medicine, Boston University
- Wilfredo F. Garcia-Beltran
- Ragon Institute of MGH, MIT and Harvard
- Vladimir Vrbanac
- Ragon Institute of MGH, MIT and Harvard
- Dylan Parsons
- Ragon Institute of MGH, MIT and Harvard
- Evan C. Lam
- Ragon Institute of MGH, MIT and Harvard
- Taylor M. Matte
- Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center
- Todd W. Dowrey
- Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center
- Sara S. Kumar
- Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center
- Mengze Li
- Division of Computational Biomedicine, School of Medicine, Boston University
- Feiya Wang
- Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center
- Anthony K. Yeung
- Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center
- Gustavo Mostoslavsky
- Center for Regenerative Medicine (CReM), Boston University and Boston Medical Center
- Ruben Dries
- Section of Hematology and Medical Oncology, School of Medicine, Boston University
- Joshua D. Campbell
- Division of Computational Biomedicine, School of Medicine, Boston University
- Anna C. Belkina
- Department of Pathology and Laboratory Medicine, School of Medicine, Boston University
- Alejandro B. Balazs
- Ragon Institute of MGH, MIT and Harvard
- George J. Murphy
- Section of Hematology and Medical Oncology, School of Medicine, Boston University
- DOI
- https://doi.org/10.1038/s41467-022-28616-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
During human embryonic development, haematopoietic stem cells of the foetal liver undergo expansion, while retaining engraftment capacity. Here the authors apply CITE-seq to profile single cells from a human foetal liver, identifying a molecular signature of engraftment potential
