Taiwanese Journal of Obstetrics & Gynecology (Aug 2016)
Uterine sarcoma Part II—Uterine endometrial stromal sarcoma: The TAG systematic review
- Huann-Cheng Horng,
- Kuo-Chang Wen,
- Peng-Hui Wang,
- Yi-Jen Chen,
- Ming-Shyen Yen,
- Heung-Tat Ng,
- Yen-Hou Chang,
- Yi Chang,
- Hsiang-Tai Chao,
- Kuan-Chong Chao,
- Chi-Mu Chuang,
- Chi-Hong Ho,
- Chen-Yu Huang,
- Zhi-Chen Hung,
- Ling-Yu Jiang,
- Hei-Yu Lau,
- Hsin-Yang Li,
- Chi-Yao Lin,
- Chia-Hao Liu,
- Pi-Lin Sun,
- Nae-Fang Twu,
- Hua-Hsi Wu,
- Hann-Chin Yu,
- Fong-Yuan Ju,
- Chih-Ping Tsai,
- Wen-Hsun Chang,
- Yen-Mei Hsu,
- Na-Rong Lee,
- Chih-Yao Chen,
- Ting-Chen Chang,
- Wen-Chun Chang,
- Chii-Hou Chen,
- Ruey-Jian Chen,
- Song-Nan Chow,
- Yih-Ron Lien,
- Bor-Ching Sheu,
- Pao-Ling Torng,
- Men-Luh Yen,
- Wen-Ling Lee,
- Kuan-Chin Wang,
- Chih-Long Chang,
- Chih-Ping Chen,
- Jen-Ruei Chen,
- Tze-Chien Chen,
- Jian-Pei Huang,
- Ming-Chao Huang,
- Yeou-Lih Wang,
- Cheng-Chang Chang,
- Jah-Yao Liu,
- Her-Young Su,
- Yu-Chi Wang,
- Mu-Hsien Yu,
- Lee-Wen Huang,
- Kok-Min Seow,
- Tsung-Hsuan Lai,
- Fa-Kung Lee,
- Ching-Hui Chen,
- Ben-Shian Huang,
- Sheng-Mou Hsiao,
- Hsu-Dong Sun,
- Wen-Yih Wu,
- Sen-Wen Teng,
- Kuo-Hu Chen,
- Jeng-Hsiu Hung,
- Hung-Cheng Lai,
- Chiou-Chung Yuan,
- Ching-Hung Hsieh,
- Chin-Jung Wang,
- Shing-Jyh Chang,
- Man-Jung Hung,
- Shih-Tien Hsu,
- Yu-Min Ke,
- Chien-Hsing Lu,
- Lou Sun,
- Wei-Chun Chang,
- Yao-Ching Hung,
- Wu-Chou Lin,
- Po-Hui Wang,
- Tze-Ho Chen,
- Yiu-Tai Li,
- Meng-Hsing Wu,
- Kuo-Feng Huang,
- Hung-Chun Fu,
- San-Nung Chen,
- An-Jen Chiang,
- Ju-Yueh Li,
- Li-Te Lin,
- Hsiao-Wen Tsai,
- Kuan-Hao Tsui
Affiliations
- Huann-Cheng Horng
- Kuo-Chang Wen
- Peng-Hui Wang
- Yi-Jen Chen
- Ming-Shyen Yen
- Heung-Tat Ng
- Yen-Hou Chang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Yi Chang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Hsiang-Tai Chao
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Kuan-Chong Chao
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Chi-Mu Chuang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Chi-Hong Ho
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Chen-Yu Huang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Zhi-Chen Hung
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Ling-Yu Jiang
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Hei-Yu Lau
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Hsin-Yang Li
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Chi-Yao Lin
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Chia-Hao Liu
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Pi-Lin Sun
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Nae-Fang Twu
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Hua-Hsi Wu
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Hann-Chin Yu
- Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Fong-Yuan Ju
- Department of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- Chih-Ping Tsai
- Emergency Department, Taipei Veterans General Hospital, Taipei, Taiwan
- Wen-Hsun Chang
- Department of Obstetrics and Gynecology, and Department of Nursing, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Yen-Mei Hsu
- Department of Obstetrics and Gynecology, and Department of Nursing, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Na-Rong Lee
- Department of Obstetrics and Gynecology, and Department of Nursing, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan
- Chih-Yao Chen
- Dianthus MFM Center Minquan, Dianthus MFM Group, and National Yang-Ming University, Taipei, Taiwan
- Ting-Chen Chang
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Wen-Chun Chang
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Chii-Hou Chen
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Ruey-Jian Chen
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Song-Nan Chow
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Yih-Ron Lien
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Bor-Ching Sheu
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Pao-Ling Torng
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Men-Luh Yen
- Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University, Taipei, Taiwan
- Wen-Ling Lee
- Department of Medicine, Cheng-Hsin General Hospital, Taipei, Taiwan
- Kuan-Chin Wang
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Chih-Long Chang
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Chih-Ping Chen
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Jen-Ruei Chen
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Tze-Chien Chen
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Jian-Pei Huang
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Ming-Chao Huang
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Yeou-Lih Wang
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan
- Cheng-Chang Chang
- Department of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
- Jah-Yao Liu
- Department of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
- Her-Young Su
- Department of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
- Yu-Chi Wang
- Department of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
- Mu-Hsien Yu
- Department of Obstetrics and Gynecology, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan
- Lee-Wen Huang
- Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
- Kok-Min Seow
- Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
- Tsung-Hsuan Lai
- Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan
- Fa-Kung Lee
- Department of Obstetrics and Gynecology, Cathay General Hospital, Taipei, Taiwan
- Ching-Hui Chen
- Department of Obstetrics and Gynecology, Taipei Medical University Hospital and Taipei Medical University, Taipei, Taiwan
- Ben-Shian Huang
- Department of Obstetrics and Gynecology, National Yang-Ming University Hospital, Ilan, Taiwan
- Sheng-Mou Hsiao
- Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
- Hsu-Dong Sun
- Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
- Wen-Yih Wu
- Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
- Sen-Wen Teng
- Department of Obstetrics and Gynecology, Cardinal Tien Hospital-Hsintien and Fu Jen Catholic University, New Taipei City, Taiwan
- Kuo-Hu Chen
- Department of Obstetrics and Gynecology, Taipei Buddhist Tzu Chi General Hospital, New Taipei City, Taiwan
- Jeng-Hsiu Hung
- Department of Obstetrics and Gynecology, Taipei Buddhist Tzu Chi General Hospital, New Taipei City, Taiwan
- Hung-Cheng Lai
- Department of Obstetrics and Gynecology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan
- Chiou-Chung Yuan
- Department of Obstetrics and Gynecology, Taipei Medical University-Shuang Ho Hospital, New Taipei City, Taiwan
- Ching-Hung Hsieh
- Department of Obstetrics and Gynecology, Clinic of Fu Jen Catholic University, New Taipei City, Taiwan
- Chin-Jung Wang
- Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, and Chang Gung University, Taoyuan, Taiwan
- Shing-Jyh Chang
- Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Hsinchu, Taiwan
- Man-Jung Hung
- Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
- Shih-Tien Hsu
- Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
- Yu-Min Ke
- Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
- Chien-Hsing Lu
- Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
- Lou Sun
- Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, Taichung, Taiwan
- Wei-Chun Chang
- Department of Obstetrics and Gynecology, China Medical University Hospital and China Medical University, Taichung, Taiwan
- Yao-Ching Hung
- Department of Obstetrics and Gynecology, China Medical University Hospital and China Medical University, Taichung, Taiwan
- Wu-Chou Lin
- Department of Obstetrics and Gynecology, China Medical University Hospital and China Medical University, Taichung, Taiwan
- Po-Hui Wang
- Department of Obstetrics and Gynecology, Chung-Shang General Hospital and Chung-Shang Medical University, Taichung, Taiwan
- Tze-Ho Chen
- Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan
- Yiu-Tai Li
- Department of Obstetrics and Gynecology, Kuo General Hospital, Tainan, Taiwan
- Meng-Hsing Wu
- Department of Obstetrics and Gynecology, National Cheng Kung University Hospital and National Cheng Kung University, Tainan, Taiwan
- Kuo-Feng Huang
- Department of Obstetrics and Gynecology, Chi-Mei Medical Center, Tainan, Taiwan
- Hung-Chun Fu
- Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
- San-Nung Chen
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- An-Jen Chiang
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- Ju-Yueh Li
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- Li-Te Lin
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- Hsiao-Wen Tsai
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- Kuan-Hao Tsui
- Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
- DOI
- https://doi.org/10.1016/j.tjog.2016.04.034
- Journal volume & issue
-
Vol. 55,
no. 4
pp. 472 – 479
Abstract
Endometrial stromal tumors are rare uterine tumors (<1%). Four main categories include endometrial stromal nodule, low-grade endometrial stromal sarcoma (LG-ESS), high-grade endometrial stromal sarcoma (HG-ESS), and uterine undifferentiated sarcoma (UUS). This review is a series of articles discussing the uterine sarcomas. LG-ESS, a hormone-dependent tumor harboring chromosomal rearrangement, is an indolent tumor with a favorable prognosis, but characterized by late recurrences even in patients with Stage I disease, suggesting the requirement of a long-term follow-up. Patients with HG-ESS, based on the identification of YWHAE-NUTM2A/B (YWHAE-FAM22A/B) gene fusion, typically present with advanced stage diseases and frequently have recurrences, usually within a few years after initial surgery. UUS is, a high-grade sarcoma, extremely rare, lacking a specific line of differentiation, which is a diagnosis of exclusion (the wastebasket category, which fails to fulfill the morphological and immunohistochemical criteria of translocation-positive ESS). Surgery is the main strategy in the management of uterine sarcoma. Due to rarity, complex biological characteristics, and unknown etiology and risk factors of uterine sarcomas, the role of adjuvant therapy is not clear. Only LG-ESS might respond to progestins or aromatase inhibitors.
Keywords
