The Egyptian Journal of Radiology and Nuclear Medicine (Jun 2016)

Added value of combined

  • Susan Adil Ali,
  • Yasser Ibrahim Abd Elkhalek

DOI
https://doi.org/10.1016/j.ejrnm.2016.03.006
Journal volume & issue
Vol. 47, no. 2
pp. 453 – 458

Abstract

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Purpose: The goal of the study was to illustrate the added value of combined 18F-FDG PET/CT over isolated CT for detection of osseous metastases in cancer patients. Patients and methods: The study included 53 patients divided into five groups of primary malignancies. 18F-PET/CT scans were performed. In this study, a lesion based analysis was performed in detailed retrograde matter for a total of 386 detected osseous lesions on CT and fused images of 18F-PET/CT. Statistical analysis including specificity, Sensitivity, negative predictive value (NPV) and positive predictive value (PPV) of each of these modalities was calculated. A final diagnosis of metastasis was confirmed by biopsy or by further clinical and radiologic workup. Results: According to lesion based analysis, the 18F-PET/CT showed 100% sensitivity, 80.8% specificity, 98.6% PPV, 100% NPV and 98.7% accuracy compared with 93.9%, 34.6%, 95.2%, 29% and 89.9%, respectively, for CT. Significant improvement of the sensitivity and specificity was found in combined 18F-PET/CT than in CT alone. Conclusion: Combined 18-F FDG PET/CT significantly improves the sensitivity and specificity of isolated CT for the detection of osseous metastases.

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