Guillain-Barre like syndrome associated with risperidone use: A case report (eng)

Abstract

Guillain-Barre Syndrome is an autoimmune response that usually occurs due to infectious or idiopathic causes. Rare case reports have also been shown to be caused by the intake of many substances and drugs. GBS cases results in 10% mortality and 25% respiratory failure. This case report describes the occurrence and termination of GBS-like syndrome following first time risperidone intake at a patient in the psychiatric ward. A 42-years old female patient without any prior psychiatric history admitted to psychiatric ward with paranoid and persecutory delusions, disorganized speech and behaviors related to systematic delusions aiming infidelity of her spouse. Risperidone 4 mg day prescribed for treatment for first time. In seventh day, neuromuscular symptoms started as dizziness, ataxia, muscle weakness and ascending paralysis. Neurological examination and consultation, imaging and lumbar puncture was performed, resulting GBS diagnosis. With the immediate transfer to intense care unit, Risperidone treatment stopped and hIG treatment administered. Patient Recovered without any physical impairment. Current case presents a GBS like syndrome associated with Risperidone treatment. There are several Atypical antipsychotic drug treatment related GBS like case reports but this is the first to be associated with Risperidone in adults. Infection related etiology was excluded by patient history but no specific antibody test or immunological survey was performed for GBS.

Keywords

• antipsychotics
• risperidone
• guillain-barre syndrome
• neuropsychiatry