Pharmacogenomics and Personalized Medicine (Sep 2022)

Contribution of ZBTB20 Polymorphisms to Esophageal Cancer Risk Among the Chinese Han Population

  • Yu S,
  • Yuan G,
  • Hu F,
  • Li Y,
  • Chen Z,
  • Zhang R,
  • Li P,
  • Chen Z,
  • Song J

Journal volume & issue
Vol. Volume 15
pp. 827 – 842


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Shuyong Yu,1,* Guihong Yuan,2,* Feixiang Hu,1,* Yongyu Li,2 Zhuang Chen,2 Ronglin Zhang,3 Ping Li,3 Zhaowei Chen,2 Jian Song4 1Department of Gastrointestinal Surgery, Hainan Cancer Hospital, Haikou, 570100, People’s Republic of China; 2Department of Gastroenterology, Hainan Cancer Hospital, Haikou, 570100, People’s Republic of China; 3Digestive Endoscopy Center, Hainan Cancer Hospital, Haikou, 570100, People’s Republic of China; 4Department of Gastroenterology, Southern University of Science and Technology Hospital, Shenzhen, 518000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian Song, #6019, Liuxian Avenue, Nanshan District, Shenzhen, Guangdong, 518000, People’s Republic of China, Email [email protected]: ZBTB20 was overexpressed in esophageal cancer (EC). The study aimed to identify genotypes of ZBTB20 polymorphisms and their correlation with EC occurrence in a Chinese Han population.Methods: Four single nucleotide polymorphisms (SNPs) in ZBTB20 were randomly selected for genotyping through Agena MassARRAY system among 525 EC patients and 522 healthy controls. Multiple genetic models were applied to assess the association of ZBTB20 polymorphisms with EC susceptibility by calculating odds ratios (ORs) with 95% confidence intervals (CIs).Results: Rs10934270 was associated with lower EC susceptibility (OR = 0.64, p = 0.004) with statistical power > 90% in overall analysis. Specifically, the correlation of rs10934270 with EC susceptibility was found in subgroups including patients with esophageal squamous cell carcinoma (ESCC), males, subjects aged ≤ 65 years, subjects with BMI ≤ 24 kg/m2, and smokers. Rs9841504 might be a risk-increasing factor for ESCC. Moreover, rs9288999 in subjects aged ≤ 65 years and rs73230612 in females were related to lower EC risk.Conclusion: Our research is the first to report that ZBTB20 rs10934270 is associated with reduced EC susceptibility in the Chinese Han population. These data provide a scientific basis for understanding the influence of the ZBTB20 gene on EC occurrence.Keywords: esophageal cancer, ZBTB20, genetic polymorphisms, genotype–phenotype analyses, FPRP analysis