Testicular involvement in mantle cell lymphoma: An analysis of 16 patients.

Samer Alkhalili; Dharmini Manogna; Hana Safah; Elizabeth Ellent; Walter Beversdorf; Ruby Arora; Nakhle S. Saba

Leukemia Research Reports (Jan 2023)

Testicular involvement in mantle cell lymphoma: An analysis of 16 patients.

Samer Alkhalili,
Dharmini Manogna,
Hana Safah,
Elizabeth Ellent,
Walter Beversdorf,
Ruby Arora,
Nakhle S. Saba

Affiliations

Samer Alkhalili: Deming Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, United States
Dharmini Manogna: Section of Hematology and Medical Oncology, Deming Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, United States
Hana Safah: Section of Hematology and Medical Oncology, Deming Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, United States
Elizabeth Ellent: Hematology and Medical Oncology, LCMC Health, 4513 Westbank Expressway, Marrero, LA 70072, United States
Walter Beversdorf: Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, United States
Ruby Arora: Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, United States
Nakhle S. Saba: Section of Hematology and Medical Oncology, Deming Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA 70112, United States; Corresponding author at: School of Medicine, Deming Department of Medicine, Section of Hematology & Medical Oncology, 1430 Tulane Ave. #8578, New Orleans, LA 70112, United States.

Journal volume & issue: Vol. 20
p. 100397

Abstract

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Mantle cell lymphoma (MCL) with testicular involvement is a rare presentation and only a few cases have been described in the literature. We present a case of MCL with testicular involvement and the first analysis of all previously reported cases assessing trends in immunohistochemical features, prognostic indicators, and survival. Our data suggest that among all MCL, testicular MCL is more likely to present with aggressive features: blastoid/pleomorphic morphology, high Ki-67 proliferative index, and CNS involvement. Testicular MCL is also associated with shorter overall survival.

Published in Leukemia Research Reports

ISSN: 2213-0489 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: http://www.journals.elsevier.com/leukemia-research-reports/

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Abstract

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