Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation

Mergim Ramosaj; Sofia Madsen; Vanille Maillard; Valentina Scandella; Daniel Sudria-Lopez; Naoya Yuizumi; Ludovic Telley; Marlen Knobloch

doi:10.1038/s41467-021-27365-7

Nature Communications (Dec 2021)

Lipid droplet availability affects neural stem/progenitor cell metabolism and proliferation

Mergim Ramosaj,
Sofia Madsen,
Vanille Maillard,
Valentina Scandella,
Daniel Sudria-Lopez,
Naoya Yuizumi,
Ludovic Telley,
Marlen Knobloch

Affiliations

Mergim Ramosaj: Department of Biomedical Sciences, University of Lausanne
Sofia Madsen: Department of Biomedical Sciences, University of Lausanne
Vanille Maillard: Department of Biomedical Sciences, University of Lausanne
Valentina Scandella: Department of Biomedical Sciences, University of Lausanne
Daniel Sudria-Lopez: Department of Biomedical Sciences, University of Lausanne
Naoya Yuizumi: Graduate School of Pharmaceutical Sciences, The University of Tokyo
Ludovic Telley: Department of Fundamental Neurosciences, University of Lausanne
Marlen Knobloch: Department of Biomedical Sciences, University of Lausanne

DOI: https://doi.org/10.1038/s41467-021-27365-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Lipid droplets (LDs) are central to lipid metabolism, which is known to regulate neural stem cell behavior. Here, the authors show that LDs influence neural stem cell proliferation and metabolic activity and change upon differentiation or quiescence.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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