Enantioselective [3+3] atroposelective annulation catalyzed by N-heterocyclic carbenes

Abstract

Axially chiral compounds are commonly found in nature. Here, the authors show the highly enantioselective construction of axially chiral biaryls via an N-heterocyclic carbenes-catalyzed [3+3] atroposelective annulation of ynals with cyclic 1,3-diones.