Frontiers in Neuroscience (Feb 2022)
Integrative Functional, Molecular, and Transcriptomic Analyses of Altered Intrinsic Timescale Gradient in Depression
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Shaoqiang Han,
- Ruiping Zheng,
- Ruiping Zheng,
- Ruiping Zheng,
- Ruiping Zheng,
- Ruiping Zheng,
- Ruiping Zheng,
- Ruiping Zheng,
- Shuying Li,
- Bingqian Zhou,
- Bingqian Zhou,
- Bingqian Zhou,
- Bingqian Zhou,
- Bingqian Zhou,
- Bingqian Zhou,
- Bingqian Zhou,
- Yu Jiang,
- Yu Jiang,
- Yu Jiang,
- Yu Jiang,
- Yu Jiang,
- Yu Jiang,
- Yu Jiang,
- Caihong Wang,
- Caihong Wang,
- Caihong Wang,
- Caihong Wang,
- Caihong Wang,
- Caihong Wang,
- Caihong Wang,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Yarui Wei,
- Jianyue Pang,
- Hengfen Li,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yong Zhang,
- Yuan Chen,
- Yuan Chen,
- Yuan Chen,
- Yuan Chen,
- Yuan Chen,
- Yuan Chen,
- Yuan Chen,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng,
- Jingliang Cheng
Affiliations
- Shaoqiang Han
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Shaoqiang Han
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Ruiping Zheng
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Ruiping Zheng
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Ruiping Zheng
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Ruiping Zheng
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Ruiping Zheng
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Ruiping Zheng
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Ruiping Zheng
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Shuying Li
- Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Bingqian Zhou
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Bingqian Zhou
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Bingqian Zhou
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Bingqian Zhou
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Bingqian Zhou
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Bingqian Zhou
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Bingqian Zhou
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Yu Jiang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yu Jiang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Yu Jiang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Yu Jiang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Yu Jiang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Yu Jiang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Yu Jiang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Caihong Wang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Caihong Wang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Caihong Wang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Caihong Wang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Caihong Wang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Caihong Wang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Caihong Wang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Yarui Wei
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yarui Wei
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Yarui Wei
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Yarui Wei
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Yarui Wei
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Yarui Wei
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Yarui Wei
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Jianyue Pang
- Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Hengfen Li
- Department of Psychiatry, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yong Zhang
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yong Zhang
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Yong Zhang
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Yong Zhang
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Yong Zhang
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Yuan Chen
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Yuan Chen
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Yuan Chen
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Yuan Chen
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Yuan Chen
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Yuan Chen
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Yuan Chen
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory for Functional Magnetic Resonance Imaging and Molecular Imaging of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Engineering Technology Research Center for Detection and Application of Brain Function of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Engineering Research Center of Medical Imaging Intelligent Diagnosis and Treatment of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Magnetic Resonance and Brain Function of Henan Province, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Brain Function and Cognitive Magnetic Resonance Imaging of Zhengzhou, Zhengzhou, China
- Jingliang Cheng
- Key Laboratory of Imaging Intelligence Research Medicine of Henan Province, Zhengzhou, China
- DOI
- https://doi.org/10.3389/fnins.2022.826609
- Journal volume & issue
-
Vol. 16
Abstract
The pathophysiology and pharmacology of depression are hypothesized to be related to the imbalance of excitation–inhibition that gives rise to hierarchical dynamics (or intrinsic timescale gradient), further supporting a hierarchy of cortical functions. On this assumption, intrinsic timescale gradient is theoretically altered in depression. However, it remains unknown. We investigated altered intrinsic timescale gradient recently developed to measure hierarchical brain dynamics gradient and its underlying molecular architecture and brain-wide gene expression in depression. We first presented replicable intrinsic timescale gradient in two independent Chinese Han datasets and then investigated altered intrinsic timescale gradient and its possible underlying molecular and transcriptional bases in patients with depression. As a result, patients with depression showed stage-specifically shorter timescales compared with healthy controls according to illness duration. The shorter timescales were spatially correlated with monoamine receptor/transporter densities, suggesting the underlying molecular basis of timescale aberrance and providing clues to treatment. In addition, we identified that timescale aberrance-related genes ontologically enriched for synapse-related and neurotransmitter (receptor) terms, elaborating the underlying transcriptional basis of timescale aberrance. These findings revealed atypical timescale gradient in depression and built a link between neuroimaging, transcriptome, and neurotransmitter information, facilitating an integrative understanding of depression.
Keywords
- first-episode depression
- gene expression profiling
- fMRI
- intrinsic timescale gradient
- neurotransmitter
