Rossijskij Vestnik Perinatologii i Pediatrii (Nov 2018)

PARTICIPATION OF VITAMIN D IN PATHOGENESIS OF CARDIOVASCULAR DISEASES

  • A. N. Kolesnikov,
  • A. V. Dubovaya,
  • Yu. V. Udovitchenko

DOI
https://doi.org/10.21508/1027-4065-2018-63-5-43-50
Journal volume & issue
Vol. 63, no. 5
pp. 43 – 50

Abstract

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The article presents data of experimental and clinical studies devoted to the influence of vitamin D on the origin and progression of the cardiovascular diseases: arterial hypertension, atherosclerosis, coronary heart disease, cardiac rhythm disturbances. The results of the studies indicate that a pronounced deficiency of vitamin D is highly correlated with sudden cardiac death, cardiovascular catastrophes, and overall mortality. The decrease in vitamin D is followed by an increase in total cholesterol, low-density lipoproteins and triglycerides, an increase in the heart rate and the level of systolic blood pressure. The Meta-analyzes of randomized controlled trials demonstrated that the addition of vitamin D to treatment and rehabilitation measures of the patients with cardiovascular disease helps to reduce overall mortality.

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