Case Reports in Oncology (Jan 2021)

Metastasis-Directed Radiotherapy for Oligoprogressive Castration-Resistant Prostate Cancer Recurrence Revealed by Choline PET/CT

  • Kazuhiro Kitajima,
  • Shingo Yamamoto,
  • Masayuki Fujiwara,
  • Hitomi Suzuki,
  • Nahomi Yoshimura,
  • Ryo Kunimoto,
  • Hiroyuki Yokoyama,
  • Hisashi Komoto,
  • Yusuke Yamada,
  • Seiji Nagasawa,
  • Akihiro Kanematsu,
  • Ryoong-Jin Oh,
  • Koichiro Yamakado

DOI
https://doi.org/10.1159/000512068
Journal volume & issue
Vol. 14, no. 1
pp. 13 – 16

Abstract

Read online

We report a 49-year-old male with castration-resistant prostate cancer (CRPC) with oligometastasis diagnosed by 11C-choline positron emission tomography-computed tomography (PET/CT) and treated with target radiotherapy. In the diagnosis of CRPC (serum prostate-specific antigen [PSA] level of 6.53 ng/mL after maximum androgen blockade (MAB) therapy, high-dose brachytherapy, and external beam radiotherapy), 11C-choline PET/CT detected one tiny obturator lymph node metastasis which fluorodeoxyglucose PET/CT could not detect. He underwent intensity-modulated radiation therapy and MAB was restarted. The PSA value decreased and reached nadir (0.091 ng/mL) after 6 months. The time to PSA progression was 10 months. The choline PET/CT finding and the corresponding local treatment could play an important role in the management sequence of oligoprogressive CRPC.

Keywords