Nature Communications (Dec 2019)
Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
- Khadijah A. Mitchell,
- Noah Nichols,
- Wei Tang,
- Jennifer Walling,
- Holly Stevenson,
- Marbin Pineda,
- Roxana Stefanescu,
- Daniel C. Edelman,
- Andrew T. Girvin,
- Adriana Zingone,
- Sanju Sinha,
- Elise Bowman,
- Emily L. Rossi,
- Rony F. Arauz,
- Yuelin Jack Zhu,
- Justin Lack,
- Elizabeth Weingartner,
- Joshua J. Waterfall,
- Sharon R. Pine,
- John Simmons,
- Paul Meltzer,
- Bríd M. Ryan
Affiliations
- Khadijah A. Mitchell
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Noah Nichols
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Wei Tang
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Jennifer Walling
- Genetics Branch, Center for Cancer Research, National Cancer Institute
- Holly Stevenson
- Genetics Branch, Center for Cancer Research, National Cancer Institute
- Marbin Pineda
- Genetics Branch, Center for Cancer Research, National Cancer Institute
- Roxana Stefanescu
- Palantir Technologies, 1025 Thomas Jefferson St
- Daniel C. Edelman
- Genetics Branch, Center for Cancer Research, National Cancer Institute
- Andrew T. Girvin
- Palantir Technologies, 1025 Thomas Jefferson St
- Adriana Zingone
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Sanju Sinha
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Elise Bowman
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Emily L. Rossi
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Rony F. Arauz
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- Yuelin Jack Zhu
- Genetics Branch, Center for Cancer Research, National Cancer Institute
- Justin Lack
- NIAID Collaborative Bioinformatics Resource, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Elizabeth Weingartner
- Personal Genome Diagnostics
- Joshua J. Waterfall
- Genetics Branch, Center for Cancer Research, National Cancer Institute
- Sharon R. Pine
- Rutgers Cancer Institute of New Jersey, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey
- John Simmons
- Personal Genome Diagnostics
- Paul Meltzer
- Genetics Branch, Center for Cancer Research, National Cancer Institute
- Bríd M. Ryan
- Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-019-13732-y
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 7
Abstract
Lung cancer etiology has largely been studied in homogenous populations of European descent. Here, targeted sequencing in African American lung adenocarcinomas finds significantly higher prevalence of PTPRTand JAK2 mutations, validated independently by whole exome sequencing, highlighting potentially clinically actionable mutations in this population.
