Clinical and Translational Allergy (Jun 2024)
Relevance of individual bronchial symptoms for asthma diagnosis and control in patients with rhinitis: A MASK‐air study
- Bernardo Sousa‐Pinto,
- Gilles Louis,
- Rafael J. Vieira,
- Wienczyslawa Czarlewski,
- Josep M. Anto,
- Rita Amaral,
- Ana Sá‐Sousa,
- Luisa Brussino,
- G. Walter Canonica,
- Claudia Chaves Loureiro,
- Alvaro A. Cruz,
- Bilun Gemicioglu,
- Tari Haahtela,
- Maciej Kupczyk,
- Violeta Kvedariene,
- Desirée E. Larenas‐Linnemann,
- Nhân Pham‐Thi,
- Francesca Puggioni,
- Frederico S. Regateiro,
- Jan Romantowski,
- Joaquin Sastre,
- Nicola Scichilone,
- Luis Taborda‐Barata,
- Maria Teresa Ventura,
- Ioana Agache,
- Anna Bedbrook,
- Alida Benfante,
- Karl C. Bergmann,
- Sinthia Bosnic‐Anticevich,
- Matteo Bonini,
- Louis‐Philippe Boulet,
- Guy Brusselle,
- Roland Buhl,
- Lorenzo Cecchi,
- Denis Charpin,
- Elisio M. Costa,
- Stefano Del Giacco,
- Marek Jutel,
- Ludger Klimek,
- Piotr Kuna,
- Daniel Laune,
- Mika Makela,
- Mario Morais‐Almeida,
- Rachel Nadif,
- Marek Niedoszytko,
- Nikolaos G. Papadopoulos,
- Alberto Papi,
- Oliver Pfaar,
- Daniela Rivero‐Yeverino,
- Nicolas Roche,
- Boleslaw Samolinski,
- Mohamed H. Shamji,
- Aziz Sheikh,
- Charlotte Suppli Ulrik,
- Omar S. Usmani,
- Arunas Valiulis,
- Arzu Yorgancioglu,
- Torsten Zuberbier,
- Joao A. Fonseca,
- Benoit Pétré,
- Renaud Louis,
- Jean Bousquet,
- MASK‐air think tank
Affiliations
- Bernardo Sousa‐Pinto
- MEDCIDS ‐ Department of Community Medicine, Information and Health Decision Sciences Faculty of Medicine University of Porto Porto Portugal
- Gilles Louis
- Department of Public Health University of Liège Liège Belgium
- Rafael J. Vieira
- MEDCIDS ‐ Department of Community Medicine, Information and Health Decision Sciences Faculty of Medicine University of Porto Porto Portugal
- Wienczyslawa Czarlewski
- Medical Consulting Czarlewski Levallois France
- Josep M. Anto
- ISGlobal Barcelona Institute for Global Health Barcelona Spain
- Rita Amaral
- MEDCIDS ‐ Department of Community Medicine, Information and Health Decision Sciences Faculty of Medicine University of Porto Porto Portugal
- Ana Sá‐Sousa
- MEDCIDS ‐ Department of Community Medicine, Information and Health Decision Sciences Faculty of Medicine University of Porto Porto Portugal
- Luisa Brussino
- Department of Medical Sciences University of Torino Torino Italy
- G. Walter Canonica
- Department of Biomedical Sciences Humanitas University Milan Italy
- Claudia Chaves Loureiro
- Department of Pneumology Faculty of Medicine Coimbra University Hospital Coimbra Portugal
- Alvaro A. Cruz
- Fundaçao ProAR Federal University of Bahia and GARD/WHO Planning Group Salvador Bahia Brazil
- Bilun Gemicioglu
- Department of Pulmonary Diseases Faculty of Medicine Istanbul University‐Cerrahpaşa Cerrahpaşa Istanbul Turkey
- Tari Haahtela
- Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland
- Maciej Kupczyk
- Division of Internal Medicine, Asthma and Allergy Barlicki University Hospital Medical University of Lodz Lodz Poland
- Violeta Kvedariene
- Institute of Clinical Medicine Clinic of Chest Diseases and Allergology Faculty of Medicine Vilnius University Vilnius Lithuania
- Desirée E. Larenas‐Linnemann
- Center of Excellence in Asthma and Allergy Médica Sur Clinical Foundation and Hospital México City Mexico
- Nhân Pham‐Thi
- Ecole Polytechnique de Palaiseau Palaiseau France
- Francesca Puggioni
- IRCCS Humanitas Research Center Personalized Medicine Asthma & Allergy Rozzano, Milan Italy
- Frederico S. Regateiro
- Allergy and Clinical Immunology Unit Centro Hospitalar e Universitário de Coimbra Coimbra Portugal
- Jan Romantowski
- Department of Allergology Medical University of Gdańsk Gdansk Poland
- Joaquin Sastre
- Allergy Service Fundacion Jimenez Diaz Autonoma University of Madrid CIBERES‐ISCIII Madrid Spain
- Nicola Scichilone
- PROMISE Department University of Palermo Palermo Italy
- Luis Taborda‐Barata
- UBIAir ‐ Clinical & Experimental Lung Centre and CICS‐UBI Health Sciences Research Centre University of Beira Interior Covilhã Portugal
- Maria Teresa Ventura
- Allergy and Clinical Immunology University of Bari Medical School Bari Italy
- Ioana Agache
- Faculty of Medicine Transylvania University Brasov Brasov Romania
- Anna Bedbrook
- MASK‐air Montpellier France
- Alida Benfante
- PROMISE Department University of Palermo Palermo Italy
- Karl C. Bergmann
- Institute of Allergology Charité—Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Sinthia Bosnic‐Anticevich
- Quality Use of Respiratory Medicines Group Woolcock Institute of Medical Research Sydney New South Wales Australia
- Matteo Bonini
- Department of Public Health and Infectious Diseases Sapienza University of Rome Rome Italy
- Louis‐Philippe Boulet
- Quebec Heart and Lung Institute Laval University Quebec City Quebec Canada
- Guy Brusselle
- Department of Respiratory Medicine Ghent University Hospital Ghent Belgium
- Roland Buhl
- Department of Pulmonary Medicine Mainz University Hospital Mainz Germany
- Lorenzo Cecchi
- SOS Allergology and Clinical Immunology USL Toscana Centro Prato Italy
- Denis Charpin
- Clinique des Bronches Allergie et Sommeil Hôpital Nord Marseille France
- Elisio M. Costa
- CINTESIS@RISE Biochemistry Lab Faculty of Pharmacy and Competence Center on Active and Healthy Ageing University of Porto Porto Portugal
- Stefano Del Giacco
- Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology University Hospital “Duilio Casula” University of Cagliari Cagliari Italy
- Marek Jutel
- Department of Clinical Immunology Wrocław Medical University Wroclaw Poland
- Ludger Klimek
- Department of Otolaryngology, Head and Neck Surgery Universitätsmedizin Mainz Mainz Germany
- Piotr Kuna
- Division of Internal Medicine, Asthma and Allergy Barlicki University Hospital Medical University of Lodz Lodz Poland
- Daniel Laune
- KYomed INNOV Montpellier France
- Mika Makela
- Skin and Allergy Hospital Helsinki University Hospital and University of Helsinki Helsinki Finland
- Mario Morais‐Almeida
- Allergy Center CUF Descobertas Hospital Lisbon Portugal
- Rachel Nadif
- Université Paris‐Saclay UVSQ University Paris‐Sud Villejuif France
- Marek Niedoszytko
- UBIAir ‐ Clinical & Experimental Lung Centre and CICS‐UBI Health Sciences Research Centre University of Beira Interior Covilhã Portugal
- Nikolaos G. Papadopoulos
- Allergy Department 2nd Pediatric Clinic University of Athens Athens Greece
- Alberto Papi
- Respiratory Medicine Department of Translational Medicine University of Ferrara Ferrara Italy
- Oliver Pfaar
- Section of Rhinology and Allergy Department of Otorhinolaryngology Head and Neck Surgery University Hospital Marburg Philipps‐Universität Marburg Marburg Germany
- Daniela Rivero‐Yeverino
- Servicio de Alergia e Inmunología clínica Hospital Universitario de Puebla Puebla México
- Nicolas Roche
- Inserm Equipe d’Epidémiologie Respiratoire Intégrative CESP Villejuif France
- Boleslaw Samolinski
- Department of Prevention of Environmental Hazards Allergology and Immunology Medical University of Warsaw Warsaw Poland
- Mohamed H. Shamji
- National Heart and Lung Institute (NHLI) Imperial College London London UK
- Aziz Sheikh
- Usher Institute The University of Edinburgh Edinburgh UK
- Charlotte Suppli Ulrik
- Department of Respiratory Medicine Copenhagen University Hospital‐Hvidovre Copenhagen Denmark
- Omar S. Usmani
- National Heart and Lung Institute (NHLI) Imperial College London London UK
- Arunas Valiulis
- Interdisciplinary Research Group of Human Ecology Institute of Clinical Medicine and Institute of Health Sciences Medical Faculty of Vilnius University Vilnius Lithuania
- Arzu Yorgancioglu
- Department of Pulmonary Diseases Faculty of Medicine Celal Bayar University Manisa Turkey
- Torsten Zuberbier
- Institute of Allergology Charité—Universitätsmedizin Berlin Corporate Member of Freie Universität Berlin and Humboldt‐Universität zu Berlin Berlin Germany
- Joao A. Fonseca
- MEDCIDS ‐ Department of Community Medicine, Information and Health Decision Sciences Faculty of Medicine University of Porto Porto Portugal
- Benoit Pétré
- Department of Public Health University of Liège Liège Belgium
- Renaud Louis
- GIGA I3 Research Group University of Liège Liège Belgium
- Jean Bousquet
- MASK‐air Montpellier France
- MASK‐air think tank
- MASK‐air think tank—See Section 6
- DOI
- https://doi.org/10.1002/clt2.12358
- Journal volume & issue
-
Vol. 14,
no. 6
pp. n/a – n/a
Abstract
Abstract Rationale It is unclear how each individual asthma symptom is associated with asthma diagnosis or control. Objectives To assess the performance of individual asthma symptoms in the identification of patients with asthma and their association with asthma control. Methods In this cross‐sectional study, we assessed real‐world data using the MASK‐air® app. We compared the frequency of occurrence of five asthma symptoms (dyspnea, wheezing, chest tightness, fatigue and night symptoms, as assessed by the Control of Allergic Rhinitis and Asthma Test [CARAT] questionnaire) in patients with probable, possible or no current asthma. We calculated the sensitivity, specificity and predictive values of each symptom, and assessed the association between each symptom and asthma control (measured using the e‐DASTHMA score). Results were validated in a sample of patients with a physician‐established diagnosis of asthma. Measurement and Main Results We included 951 patients (2153 CARAT assessments), with 468 having probable asthma, 166 possible asthma and 317 no evidence of asthma. Wheezing displayed the highest specificity (90.5%) and positive predictive value (90.8%). In patients with probable asthma, dyspnea and chest tightness were more strongly associated with asthma control than other symptoms. Dyspnea was the symptom with the highest sensitivity (76.1%) and the one consistently associated with the control of asthma as assessed by e‐DASTHMA. Consistent results were observed when assessing patients with a physician‐made diagnosis of asthma. Conclusions Wheezing and chest tightness were the asthma symptoms with the highest specificity for asthma diagnosis, while dyspnea displayed the highest sensitivity and strongest association with asthma control.
Keywords
