Nature Communications (Apr 2016)

Repulsive cues combined with physical barriers and cell–cell adhesion determine progenitor cell positioning during organogenesis

  • Azadeh Paksa,
  • Jan Bandemer,
  • Burkhard Hoeckendorf,
  • Nitzan Razin,
  • Katsiaryna Tarbashevich,
  • Sofia Minina,
  • Dana Meyen,
  • Antonio Biundo,
  • Sebastian A. Leidel,
  • Nadine Peyrieras,
  • Nir S. Gov,
  • Philipp J. Keller,
  • Erez Raz

DOI
https://doi.org/10.1038/ncomms11288
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 14

Abstract

Read online

The precise positioning of organ progenitor cells is essential for organ development and function. Here the authors use live imaging and mathematical modelling to show that the confinement of a motile progenitor cell population results from coupled physical barriers and cell-cell interactions.