Dataset of mitochondrial genome variants associated with asymptomatic atherosclerosis
Margarita A. Sazonova,
Andrey V. Zhelankin,
Valeria A. Barinova,
Vasily V. Sinyov,
Zukhra B. Khasanova,
Anton Y. Postnov,
Igor A. Sobenin,
Yuri V. Bobryshev,
Alexander N. Orekhov
Affiliations
Margarita A. Sazonova
Institute of General Pathology and Pathophysiology Russian Academy of Medical Sciences, Moscow, Russian Federation; Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russian Federation
Andrey V. Zhelankin
Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russian Federation
Valeria A. Barinova
Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russian Federation
Vasily V. Sinyov
Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russian Federation
Zukhra B. Khasanova
Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russian Federation
Anton Y. Postnov
Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russian Federation
Igor A. Sobenin
Institute of General Pathology and Pathophysiology Russian Academy of Medical Sciences, Moscow, Russian Federation; Laboratory of Medical Genetics, Russian Cardiology Research and Production Complex, Moscow, Russian Federation
Yuri V. Bobryshev
Institute of General Pathology and Pathophysiology Russian Academy of Medical Sciences, Moscow, Russian Federation; Faculty of Medicine, School of Medical Sciences, University of New South Wales, Sydney, Australia; Corresponding author at: Faculty of Medicine, University of New South Wales, Kensington, NSW 2052, Australia.Tel./fax: +612 93851217.
Alexander N. Orekhov
Institute of General Pathology and Pathophysiology Russian Academy of Medical Sciences, Moscow, Russian Federation; Institute for Atherosclerosis Research, Skolkovo Innovative Centre, Moscow Region, Russian Federation; Department of Biophysics, Biological Faculty, Moscow State University, Moscow, Russian Federation
This dataset report is dedicated to mitochondrial genome variants associated with asymptomatic atherosclerosis. These data were obtained using the method of next generation pyrosequencing (NGPS). The whole mitochondrial genome of the sample of patients from the Moscow region was analyzed. In this article the dataset including anthropometric, biochemical and clinical parameters along with detected mtDNA variants in patients with carotid atherosclerosis and healthy individuals was presented. Among 58 of the most common homoplasmic mtDNA variants found in the observed sample, 7 variants occurred more often in patients with atherosclerosis and 16 variants occurred more often in healthy individuals. Keywords: mtDNA variant, Mitochondrial genome, Homoplasmic, Asymptomatic atherosclerosis
