Nature Communications (Aug 2018)
Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
- Chen Yao,
- George Chen,
- Ci Song,
- Joshua Keefe,
- Michael Mendelson,
- Tianxiao Huan,
- Benjamin B. Sun,
- Annika Laser,
- Joseph C. Maranville,
- Hongsheng Wu,
- Jennifer E. Ho,
- Paul Courchesne,
- Asya Lyass,
- Martin G. Larson,
- Christian Gieger,
- Johannes Graumann,
- Andrew D. Johnson,
- John Danesh,
- Heiko Runz,
- Shih-Jen Hwang,
- Chunyu Liu,
- Adam S. Butterworth,
- Karsten Suhre,
- Daniel Levy
Affiliations
- Chen Yao
- Framingham Heart Study
- George Chen
- Framingham Heart Study
- Ci Song
- Framingham Heart Study
- Joshua Keefe
- Framingham Heart Study
- Michael Mendelson
- Framingham Heart Study
- Tianxiao Huan
- Framingham Heart Study
- Benjamin B. Sun
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Annika Laser
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Joseph C. Maranville
- MRL, Merck & Co., Inc
- Hongsheng Wu
- Computer Science and Networking, Wentworth Institute of Technology
- Jennifer E. Ho
- Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital
- Paul Courchesne
- Framingham Heart Study
- Asya Lyass
- Framingham Heart Study
- Martin G. Larson
- Framingham Heart Study
- Christian Gieger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Johannes Graumann
- Scientific Service Group Biomolecular Mass Spectrometry, Max Planck Institute for Heart and Lung Research, W.G. Kerckhoff Institute
- Andrew D. Johnson
- Framingham Heart Study
- John Danesh
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Heiko Runz
- MRL, Merck & Co., Inc
- Shih-Jen Hwang
- Framingham Heart Study
- Chunyu Liu
- Framingham Heart Study
- Adam S. Butterworth
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge
- Karsten Suhre
- Department of Physiology and Biophysics, Weill Cornell Medicine-Qatar, Education City
- Daniel Levy
- Framingham Heart Study
- DOI
- https://doi.org/10.1038/s41467-018-05512-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Genetic variation can influence levels of disease-related plasma proteins and, thus, contribute to the pathogenesis of complex diseases. Here, the authors perform genome-wide QTL analysis for 71 plasma proteins to identify causal proteins for coronary heart disease and provide a molecular QTL browser.
