Discovery of a Potent Antiosteoporotic Drug Molecular Scaffold Derived from Angelica sinensis and Its Bioinspired Total Synthesis

• Jian Zou,
• Zuo-Cheng Qiu,
• Qiang-Qiang Yu,
• Jia-Ming Wu,
• Yong-Heng Wang,
• Ke-Da Shi,
• Yi-Fang Li,
• Rong-Rong He,
• Ling Qin,
• Xin-Sheng Yao,
• Xin-Luan Wang,
• Hao Gao

Affiliations

Jian Zou

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, People’s Republic of China

Zuo-Cheng Qiu

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, People’s Republic of China

Qiang-Qiang Yu

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, People’s Republic of China

Jia-Ming Wu

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, People’s Republic of China

Yong-Heng Wang

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, People’s Republic of China

Ke-Da Shi

Translational Medicine R&D Center, Institute of Biomedical and Health Engineering/Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of China

Yi-Fang Li

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, People’s Republic of China

Rong-Rong He

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, People’s Republic of China

Ling Qin

Translational Medicine R&D Center, Institute of Biomedical and Health Engineering/Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of China

Xin-Sheng Yao

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, People’s Republic of China

Xin-Luan Wang

Translational Medicine R&D Center, Institute of Biomedical and Health Engineering/Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, People’s Republic of China

Hao Gao

Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, People’s Republic of China