Nature Communications (Jul 2018)
The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel
Abstract
The capsaicin receptor TRPV1 has been structurally characterized, but the capsaicin activation dynamics remain elusive. Here authors use fluorescent unnatural amino acid incorporation, computational modeling and Φ-analysis to derive the capsaicin-bound open state model and reveal the capsaicin induced conformational changes.
