The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy

Leif Oltedal; Hauke Bartsch; Ole Johan Evjenth Sørhaug; Ute Kessler; Christopher Abbott; Annemieke Dols; Max L Stek; Lars Ersland; Louise Emsell; Philip van Eijndhoven; Miklos Argyelan; Indira Tendolkar; Pia Nordanskog; Paul Hamilton; Martin Balslev Jorgensen; Iris E Sommer; Sophie M Heringa; Bogdan Draganski; Ronny Redlich; Udo Dannlowski; Harald Kugel; Filip Bouckaert; Pascal Sienaert; Amit Anand; Randall Espinoza; Katherine L Narr; Dominic Holland; Anders M Dale; Ketil J Oedegaard

doi:10.1016/j.nicl.2017.02.009

NeuroImage: Clinical (Jan 2017)

The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy

Leif Oltedal,
Hauke Bartsch,
Ole Johan Evjenth Sørhaug,
Ute Kessler,
Christopher Abbott,
Annemieke Dols,
Max L Stek,
Lars Ersland,
Louise Emsell,
Philip van Eijndhoven,
Miklos Argyelan,
Indira Tendolkar,
Pia Nordanskog,
Paul Hamilton,
Martin Balslev Jorgensen,
Iris E Sommer,
Sophie M Heringa,
Bogdan Draganski,
Ronny Redlich,
Udo Dannlowski,
Harald Kugel,
Filip Bouckaert,
Pascal Sienaert,
Amit Anand,
Randall Espinoza,
Katherine L Narr,
Dominic Holland,
Anders M Dale,
Ketil J Oedegaard

Affiliations

Leif Oltedal: Department of Clinical Medicine, University of Bergen, Bergen, Norway
Hauke Bartsch: Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA
Ole Johan Evjenth Sørhaug: Department of Clinical Medicine, University of Bergen, Bergen, Norway
Ute Kessler: Department of Clinical Medicine, University of Bergen, Bergen, Norway
Christopher Abbott: Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, USA
Annemieke Dols: VUmc Amsterdam/GGZinGeest, Amsterdam, Netherlands
Max L Stek: VUmc Amsterdam/GGZinGeest, Amsterdam, Netherlands
Lars Ersland: Department of Clinical Engineering, Haukeland University Hospital, Bergen, Norway
Louise Emsell: KU Leuven, University Psychiatric Center KU Leuven, Leuven, Belgium
Philip van Eijndhoven: Donders Institute for Brain, Cognition and Behavior, Department of Psychiatry, Nijmegen, Netherlands
Miklos Argyelan: Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, New York, USA
Indira Tendolkar: Donders Institute for Brain, Cognition and Behavior, Department of Psychiatry, Nijmegen, Netherlands
Pia Nordanskog: Center for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Paul Hamilton: Center for Social and Affective Neuroscience, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Martin Balslev Jorgensen: Psychiatric Center Copenhagen, Copenhagen, Denmark
Iris E Sommer: Brain Center Rudolf Magnus, University Medical Center, Utrecht, Utrecht, Netherlands
Sophie M Heringa: Brain Center Rudolf Magnus, University Medical Center, Utrecht, Utrecht, Netherlands
Bogdan Draganski: LREN, Department of Clinical Neurosciences – CHUV, University Lausanne, Switzerland
Ronny Redlich: Department of Psychiatry, University of Münster, Germany
Udo Dannlowski: Department of Psychiatry, University of Münster, Germany
Harald Kugel: Department of Clinical Radiology, University of Münster, Germany
Filip Bouckaert: KU Leuven, University Psychiatric Center KU Leuven, Academic center for ECT and Neurostimulation (AcCENT), Kortenberg, Belgium.
Pascal Sienaert: KU Leuven, University Psychiatric Center KU Leuven, Academic center for ECT and Neurostimulation (AcCENT), Kortenberg, Belgium.
Amit Anand: Cleveland Clinic, Center for Behavioral Health, Cleveland, USA
Randall Espinoza: Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA), CA, USA
Katherine L Narr: Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (UCLA), CA, USA
Dominic Holland: Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA
Anders M Dale: Center for Multimodal Imaging and Genetics, University of California, San Diego, La Jolla, CA, USA
Ketil J Oedegaard: Department of Clinical Medicine, University of Bergen, Bergen, Norway

DOI: https://doi.org/10.1016/j.nicl.2017.02.009
Journal volume & issue: Vol. 14, no. C
pp. 422 – 432

Abstract

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Major depression, currently the world's primary cause of disability, leads to profound personal suffering and increased risk of suicide. Unfortunately, the success of antidepressant treatment varies amongst individuals and can take weeks to months in those who respond. Electroconvulsive therapy (ECT), generally prescribed for the most severely depressed and when standard treatments fail, produces a more rapid response and remains the most effective intervention for severe depression. Exploring the neurobiological effects of ECT is thus an ideal approach to better understand the mechanisms of successful therapeutic response. Though several recent neuroimaging studies show structural and functional changes associated with ECT, not all brain changes associate with clinical outcome. Larger studies that can address individual differences in clinical and treatment parameters may better target biological factors relating to or predictive of ECT-related therapeutic response. We have thus formed the Global ECT-MRI Research Collaboration (GEMRIC) that aims to combine longitudinal neuroimaging as well as clinical, behavioral and other physiological data across multiple independent sites. Here, we summarize the ECT sample characteristics from currently participating sites, and the common data-repository and standardized image analysis pipeline developed for this initiative. This includes data harmonization across sites and MRI platforms, and a method for obtaining unbiased estimates of structural change based on longitudinal measurements with serial MRI scans. The optimized analysis pipeline, together with the large and heterogeneous combined GEMRIC dataset, will provide new opportunities to elucidate the mechanisms of ECT response and the factors mediating and predictive of clinical outcomes, which may ultimately lead to more effective personalized treatment approaches.

Published in NeuroImage: Clinical

ISSN: 2213-1582 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/neuroimage-clinical/

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