Nature Communications (Jan 2020)

Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation

  • D. Wragg,
  • Q. Liu,
  • Z. Lin,
  • V. Riggio,
  • C. A. Pugh,
  • A. J. Beveridge,
  • H. Brown,
  • D. A. Hume,
  • S. E. Harris,
  • I. J. Deary,
  • A. Tenesa,
  • J. G. D. Prendergast

DOI
https://doi.org/10.1038/s41467-019-13762-6
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

Read online

For most human genes nearby regulatory variants explain only a small proportion of their expression variation between individuals. Here the authors show how the impact of a gene’s set of nearby regulatory variant is often linked to the expression levels of distal genes, providing insights into gene networks.