INFLUENCE OF HYALURONIC ACID IN PERIODONTAL TISSUE REGENERATION

Abstract

Hyaluronic acid is a high molecular weight polysaccharide (glycosaminoglycan), which plays a vital role in the functioning of extracellular matrices, including those of mineralized and non-mineralized periodontal tissues. Hyaluronic acid is also important because of its numerous actions in the mechanisms associated with inflammation and the wound healing process. Hyaluronic acid has been identified in all periodontal tissues in varying quantities, being more prominent in the non-mineralized tissues, such as gingiva and periodontal ligament, compared to mineralized tissues, such as the cement and alveolar bone. Preliminary evidence suggests that hyaluronic acid is a very promising candidate as a mediator of periodontal tissue regeneration and periodontal disease treatment, by promoting a rapid remission of symptoms, not only to the marginal gingiva, but also to the deeper seated periodontal tissues. However, further researches for the therapeutic effects of hyaluronic acid in periodontal disease sites are essential to be fully realized the true benefits of hyaluronic administration in periodontal tissue regeneration..

Keywords

• hyaluronic acid
• gingival inflammation
• periodontal disease
• periodontal reparation