RIF1 promotes replication fork protection and efficient restart to maintain genome stability

Chirantani Mukherjee; Vivek Tripathi; Eleni Maria Manolika; Anne Margriet Heijink; Giulia Ricci; Sarra Merzouk; H. Rudolf de Boer; Jeroen Demmers; Marcel A. T. M. van Vugt; Arnab Ray Chaudhuri

doi:10.1038/s41467-019-11246-1

Nature Communications (Jul 2019)

RIF1 promotes replication fork protection and efficient restart to maintain genome stability

Chirantani Mukherjee,
Vivek Tripathi,
Eleni Maria Manolika,
Anne Margriet Heijink,
Giulia Ricci,
Sarra Merzouk,
H. Rudolf de Boer,
Jeroen Demmers,
Marcel A. T. M. van Vugt,
Arnab Ray Chaudhuri

Affiliations

Chirantani Mukherjee: Department of Molecular Genetics, Erasmus University Medical Center
Vivek Tripathi: Department of Molecular Genetics, Erasmus University Medical Center
Eleni Maria Manolika: Department of Molecular Genetics, Erasmus University Medical Center
Anne Margriet Heijink: Department of Medical Oncology, University Medical Center Groningen, University of Groningen
Giulia Ricci: Department of Molecular Genetics, Erasmus University Medical Center
Sarra Merzouk: Department of Developmental Biology, Erasmus University Medical Center
H. Rudolf de Boer: Department of Medical Oncology, University Medical Center Groningen, University of Groningen
Jeroen Demmers: Department of Biochemistry, Erasmus University Medical Center
Marcel A. T. M. van Vugt: Department of Medical Oncology, University Medical Center Groningen, University of Groningen
Arnab Ray Chaudhuri: Department of Molecular Genetics, Erasmus University Medical Center

DOI: https://doi.org/10.1038/s41467-019-11246-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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Replication fork degradation can result in genome instability. Here authors reveal a role for Rif1 protein in protecting stalled replication forks from undergoing extensive, DNA2-dependent, degradation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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