The effect of temozolomide on Hsp60 and Hsp70 expression in extracellular vesicles derived from U87MG glioma cells

Pekmez Murat; Kılcı Cansu

doi:10.1515/tjb-2021-0111

Türk Biyokimya Dergisi (Sep 2021)

The effect of temozolomide on Hsp60 and Hsp70 expression in extracellular vesicles derived from U87MG glioma cells

Pekmez Murat,
Kılcı Cansu

Affiliations

Pekmez Murat: Molecular Biology and Genetics, Istanbul University, Istanbul, Turkey
Kılcı Cansu: Department of Molecular Biology and Genetics, Institute of Graduate Studies in Sciences, Istanbul, Turkey

DOI: https://doi.org/10.1515/tjb-2021-0111
Journal volume & issue: Vol. 47, no. 1
pp. 85 – 95

Abstract

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Temozolomide (TMZ) is an effective drug for glioblastoma multiforme (GBM), but the mechanism underlying TMZ resistance is poorly understood. New evidence has revealed that the release of heat shock proteins (Hsps) derived from extracellular vesicles (EVs) play an important role in cancer progression by modulating tumor microenvironment and cellular cross-talk. This study aims to evaluate the effects of TMZ on the expression of EV-derived and cellular Hsps and cell motility in U87MG human glioblastoma cell line.

Published in Türk Biyokimya Dergisi

ISSN: 1303-829X (Online)
Publisher: De Gruyter
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.degruyter.com/journal/key/tjb/html

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