Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome

Didier Dewailly; Anne-Laure Barbotin; Anne-Laure Barbotin; Agathe Dumont; Agathe Dumont; Sophie Catteau-Jonard; Sophie Catteau-Jonard; Geoffroy Robin; Geoffroy Robin; Geoffroy Robin

doi:10.3389/fendo.2020.00641

Frontiers in Endocrinology (Sep 2020)

Role of Anti-Müllerian Hormone in the Pathogenesis of Polycystic Ovary Syndrome

Didier Dewailly,
Anne-Laure Barbotin,
Anne-Laure Barbotin,
Agathe Dumont,
Agathe Dumont,
Sophie Catteau-Jonard,
Sophie Catteau-Jonard,
Geoffroy Robin,
Geoffroy Robin,
Geoffroy Robin

Affiliations

Didier Dewailly: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, Lille, France
Anne-Laure Barbotin: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, Lille, France
Anne-Laure Barbotin: CHU Lille, Institut de Biologie de la Reproduction-Spermiologie-CECOS, Hôpital Jeanne de Flandre, Lille, France
Agathe Dumont: CHU Lille, Unité Fonctionnelle de Gynécologie Endocrinienne, Service de Gynécologie Médicale, Orthogénie et Sexologie, Hôpital Jeanne de Flandre, Lille, France
Agathe Dumont: CHU Lille, Service d'Assistance Médicale à la Procréation et Préservation de la Fertilité, Hôpital Jeanne de Flandre, Lille, France
Sophie Catteau-Jonard: Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, Lille, France
Sophie Catteau-Jonard: CHU Lille, Unité Fonctionnelle de Gynécologie Endocrinienne, Service de Gynécologie Médicale, Orthogénie et Sexologie, Hôpital Jeanne de Flandre, Lille, France
Geoffroy Robin: CHU Lille, Unité Fonctionnelle de Gynécologie Endocrinienne, Service de Gynécologie Médicale, Orthogénie et Sexologie, Hôpital Jeanne de Flandre, Lille, France
Geoffroy Robin: CHU Lille, Service d'Assistance Médicale à la Procréation et Préservation de la Fertilité, Hôpital Jeanne de Flandre, Lille, France
Geoffroy Robin: Lille University, EA 4308 “Gametogenesis and Gamete Quality”, Lille, France

DOI: https://doi.org/10.3389/fendo.2020.00641
Journal volume & issue: Vol. 11

Abstract

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Besides its interest for diagnosis, the finding of an elevated serum AMH level in PCOS has open major pathophysiological issues. This review addresses the three most important issues: 1- the role of AMH in the disturbed folliculogenesis of PCOS; 2- the role of AMH in the gonadotropin dysregulation of PCOS and 3- the role of AMH in the trans-generational transmission of PCOS. For each of those issues, the clinical and experimental evidences currently available are discussed and pathophysiological hypothesis are proposed.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

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