Nature Communications (2021-01-01)

Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing

  • Dandan Liang,
  • Jinfeng Xue,
  • Li Geng,
  • Liping Zhou,
  • Bo Lv,
  • Qiao Zeng,
  • Ke Xiong,
  • Huixing Zhou,
  • Duanyang Xie,
  • Fulei Zhang,
  • Jie Liu,
  • Yi Liu,
  • Li Li,
  • Jian Yang,
  • Zhigang Xue,
  • Yi-Han Chen

DOI
https://doi.org/10.1038/s41467-020-20448-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 15

Abstract

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The spontaneous bioelectrical activity of pacemaker cells in sinoatrial node (SAN) triggers the heartbeats. Here, the authors perform single-cell RNA sequencing in the mouse SAN and identify molecular and cellular features of the SAN conserved in rabbit and cynomolgus monkey, identifying a new potential SAN marker.