The Effect of Autosomal Dominant Polycystic Kidney Disease on Spirometric Parameters

Abstract

Aim:There is no enough data on pulmonary involvement in autosomal dominant polycystic kidney disease (ADPKD). The aim of this study is to examine pulmonary function test in patients with ADPKD with varying stages of renal function and to compare them with those in healthy controls.Methods:Forty-six patients with ADPKD and 43 healthy control subjects were included in the study. Pulmonary function test was performed for each patient after routine physical examination and biochemical analysis.Results:Age, gender, weight, height and smoking rate were similar in both groups. Seven patients (15.2%) had restrictive pattern and one (2.1%) had obstructive pattern in ADPKD group while one patient (2.3%) had obstructive pattern and two (4.6%) had restrictive pattern in the control group. The frequency of restrictive pattern was not significantly higher (p=0.15), but forced vital capacity volume was significantly lower in the patient group (p=0.04).Conclusion:Restrictive spirometric pattern was more prevalent in the patient group, but there was no statistically significant difference. It is thought that the difference may be statistically significant when the study is performed with kidney volume analysis and larger patient population.

Keywords

• autosomal dominant polycystic kidney disease
• lung
• pulmonary function test
• spirometry