Thyroid hormone receptor α controls larval intestinal epithelial cell death by regulating the CDK1 pathway

Abstract

Tanizaki et al use ChIP-Seq to identify over 3000 Thyroid hormone (T3) receptor (TR)-bound genes in the intestine of premetamorphic wild type Xenopus tropicalis tadpoles and in TRα-knockouts. They show that treatment of tadpoles with cell cycle inhibitors blocked T3-induced intestinal remodeling, suggesting that TRα-dependent activation of the cell cycle is important for T3-induced apoptosis during intestinal remodelling.