Nature Communications (Jan 2017)
Disruption of cardiac cholinergic neurons enhances susceptibility to ventricular arrhythmias
- Christiane Jungen,
- Katharina Scherschel,
- Christian Eickholt,
- Pawel Kuklik,
- Niklas Klatt,
- Nadja Bork,
- Tim Salzbrunn,
- Fares Alken,
- Stephan Angendohr,
- Christiane Klene,
- Janos Mester,
- Nikolaj Klöcker,
- Marieke W. Veldkamp,
- Udo Schumacher,
- Stephan Willems,
- Viacheslav O. Nikolaev,
- Christian Meyer
Affiliations
- Christiane Jungen
- Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf
- Katharina Scherschel
- Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf
- Christian Eickholt
- Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf
- Pawel Kuklik
- Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf
- Niklas Klatt
- Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf
- Nadja Bork
- DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck
- Tim Salzbrunn
- Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf
- Fares Alken
- Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf
- Stephan Angendohr
- Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf
- Christiane Klene
- Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf
- Janos Mester
- Department of Nuclear Medicine, University Medical Center Hamburg-Eppendorf
- Nikolaj Klöcker
- Institute of Neural and Sensory Physiology, Medical Faculty, University of Düsseldorf
- Marieke W. Veldkamp
- Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam
- Udo Schumacher
- Institute of Anatomy and Experimental Morphology, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf
- Stephan Willems
- Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf
- Viacheslav O. Nikolaev
- DZHK (German Center for Cardiovascular Research), partner site Hamburg/Kiel/Lübeck
- Christian Meyer
- Department of Cardiology-Electrophysiology, cardiac Neuro- and Electrophysiology Research Group (cNEP), University Heart Center, University Hospital Hamburg-Eppendorf
- DOI
- https://doi.org/10.1038/ncomms14155
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Catheter ablation is a common therapy for atrial fibrillation but disrupts cardiac cholinergic neurons. Here the authors report that cholinergic neurons innervate heart ventricles and show that their ablation leads to increased susceptibility to ventricular arrhythmias in mouse models and in patients.
