Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR

Deepika Vasudevan; Sarah D. Neuman; Amy Yang; Lea Lough; Brian Brown; Arash Bashirullah; Timothy Cardozo; Hyung Don Ryoo

doi:10.1038/s41467-020-18453-1

Nature Communications (Sep 2020)

Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR

Deepika Vasudevan,
Sarah D. Neuman,
Amy Yang,
Lea Lough,
Brian Brown,
Arash Bashirullah,
Timothy Cardozo,
Hyung Don Ryoo

Affiliations

Deepika Vasudevan: Department of Cell Biology, New York University Grossman School of Medicine
Sarah D. Neuman: Department of Pharmaceutical Sciences, University of Wisconsin-Madison
Amy Yang: Department of Cell Biology, New York University Grossman School of Medicine
Lea Lough: Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine
Brian Brown: Department of Cell Biology, New York University Grossman School of Medicine
Arash Bashirullah: Department of Pharmaceutical Sciences, University of Wisconsin-Madison
Timothy Cardozo: Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine
Hyung Don Ryoo: Department of Cell Biology, New York University Grossman School of Medicine

DOI: https://doi.org/10.1038/s41467-020-18453-1
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Translation of ATF4 mRNA is stimulated during the integrated stress response. Here the authors show that two noncanonical translation initiation factors eIF2D and DENR are required for translational induction of ATF4 mRNA in Drosophila and human cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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