Nature Communications (Jan 2023)
Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation
- Elmo C. Saarentaus,
- Juha Karjalainen,
- Joel T. Rämö,
- Tuomo Kiiskinen,
- Aki S. Havulinna,
- Juha Mehtonen,
- Heidi Hautakangas,
- Sanni Ruotsalainen,
- Max Tamlander,
- Nina Mars,
- FINNGEN,
- Sanna Toppila-Salmi,
- Matti Pirinen,
- Mitja Kurki,
- Samuli Ripatti,
- Mark Daly,
- Tuula Palotie,
- Antti Mäkitie,
- Aarno Palotie
Affiliations
- Elmo C. Saarentaus
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Juha Karjalainen
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Joel T. Rämö
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Tuomo Kiiskinen
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Aki S. Havulinna
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Juha Mehtonen
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Heidi Hautakangas
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Sanni Ruotsalainen
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Max Tamlander
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Nina Mars
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- FINNGEN
- Sanna Toppila-Salmi
- Skin and Allergy Hospital, Helsinki University Hospital and University of Helsinki
- Matti Pirinen
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Mitja Kurki
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Samuli Ripatti
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Mark Daly
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Tuula Palotie
- Orthodontics, Department of Oral and Maxillofacial Diseases, Clinicum, Faculty of Medicine, University of Helsinki
- Antti Mäkitie
- Department of Otorhinolaryngology—Head and Neck Surgery, University of Helsinki and Helsinki University Hospital
- Aarno Palotie
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- DOI
- https://doi.org/10.1038/s41467-022-33626-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
The shared genetics between upper respiratory diseases have not been well studied. Here, the authors find shared and distinct genetic loci for pharyngeal and sinonasal inflammatory conditions, which show shared heritability with autoimmune conditions and immune deficiency, highlighting the TNFR2 pathway.
