Actoprotective action of sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio)acetate in acute hemic hypoxia

Abstract

Enough energy and good oxygen supply of the organism is necessary to maintain high performance level. Hypoxic process develops rapidly during intense physical exertion. This prevents the execution of tasks, and under certain circumstances endangers human life. Study of antihypoxic action is necessary in the study of materials that are promising for use in order to increase physical endurance. The aim of the study was to evaluate the actoprotective effect of sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio)acetate (Compound КВ-28) under conditions of acute hemic hypoxia. Materials and methods. The experiments were performed on nonlinear white rats. To simulate animal acute hemic hypoxia sodium nitrite was injected subcutaneously at a dose of 20 mg/kg 30 minutes before exercises. The test substance sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio)acetate (Compound КВ-28) at a dose of 1,7 mg/kg and reference compound 2-aetyltiobenzimidazolum hydrobromide (32,0 mg/kg) were administered prophylactically 1 hour before exercises. Compound КВ-28 and the reference drug were used at ED50 doses by swimming test. The physical endurance of animals was assessed by the forced swimming test with additional load under normothermia. Results. It was found that physical endurance of animals is greatly reduced under conditions of acute hemic hypoxia. The sign of this was reduce of control animals swimming duration in comparison with the intact group. Prophylactic administration of sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio)acetate (Compound КВ-28) (1,7 mg/kg i/p) helped to increase the body's resistance to hypoxia, that was shown by increase in average swimming test in these experimental conditions. The compound КВ-28 was compared in this study with the reference substance 2-aetyltiobenzimidazolum hydrobromide by effectiveness. Compound КВ-28 has considerably higher activity because its ED50 is 20 times less than the reference actoprotectors’. Conclusions. Sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio)acetate (Compound КВ-28) has actprotective effect in acute hemic hypoxia. This indicates that it has antihypoxic action. physical endurance; acute hemic hypoxia; sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio)acetate; 2-aetyltiobenzimidazolum hydrobromide

Keywords

• physical endurance
• acute hemic hypoxia
• 5-c]quinazolin-5-ylthio)acetate
• 2-aetyltiobenzimidazolum hydrobromide