International Journal of Preventive Medicine (Jan 2020)

The Most Important Predictors of Metabolic Syndrome Persistence after 10-year Follow-Up: YHHP Study

  • Mohammadtaghi Sareban Hassanabadi,
  • Seyed Jalil Mirhosseini,
  • Masoud Mirzaei,
  • Seyedeh Mahdieh Namayandeh,
  • Omid Beiki,
  • Fadoua Gannar,
  • Paolo Boffetta,
  • Mohammadreza Pakseresht,
  • Maryam Tabesh,
  • Nastaran Ahmadi,
  • Mahmood Kazeminasab,
  • Amin Salehi-Abargouei

DOI
https://doi.org/10.4103/ijpvm.IJPVM_215_18
Journal volume & issue
Vol. 11, no. 1
pp. 33 – 33

Abstract

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Background: Metabolic syndrome (MetS) is one of the world's largest health epidemics, and its management is a major challenge worldwide. The aim of this 10-year follow-up study was to assess the most important predictors of MetS persistence among an Iranian adult population. Methods: In this cohort study, 887 out of 2000 participants with MetS aged 20–74 years in the central part of Iran were followed-up for about 10 years from 2005–2006 to 2015–2016. MetS was defined based on the criteria of NCEP-ATP III adopted for the Iranian population. Cox proportional hazards regression was conducted to evaluate the predictors of MetS persistence in crude- and multivariate-adjusted models. Results: Our analyses showed that 648 out of 887 participants (73%) completed the follow-up and 565 (87.2%) of them had persistence of MetS after 10-year follow-up. There was a significant association between age, weight, body mass index, triglyceride, and waist circumference in participants who had MetS compared to those without MetS after 10-year follow-up (P < 0.05). There was a direct association between increases in the mean changes of systolic/diastolic blood pressure, waist circumference, and low HDL-C and risk of MetS persistence after adjusting the model for sex and age in the total population (Ptrend< 0.05). The trends were the same for women except in diastolic blood pressure. After adjustment for potential confounders, the risk of MetS persistence in men was significantly higher than women (HR = 1.98, 95% CI: 1.38–2.85, Ptrend= 0.001). Conclusions: Most of the risk factors of MetS were positively associated with persistence of MetS. Therefore, modification of lifestyle is recommended to reduce MetS.

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