Common functional localizers to enhance NHP & cross-species neuroscience imaging research
Brian E Russ,
Christopher I Petkov,
Sze Chai Kwok,
Qi Zhu,
Pascal Belin,
Wim Vanduffel,
Suliann Ben Hamed
Affiliations
Brian E Russ
Center for Biomedical Imaging and Neuromodulation, Nathan Kline Institute, Orangeburg, NY, United States; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York City, NY, United States; Department of Psychiatry, New York University at Langone, New York City, NY, United States; Corresponding authors.
Christopher I Petkov
Biosciences Institute, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom
Sze Chai Kwok
Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics Ministry of Education, Shanghai Key Laboratory of Magnetic Resonance, Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, China; Division of Natural and Applied Sciences, Duke Kunshan University, Kunshan, Jiangsu, China; NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, China
Qi Zhu
Cognitive Neuroimaging Unit, INSERM, CEA, Université Paris-Saclay, NeuroSpin Center, 91191 Gif/Yvette, France; Laboratory for Neuro-and Psychophysiology, Department of Neurosciences, KU Leuven Medical School, Leuven, 3000, Belgium
Pascal Belin
Institut de Neurosciences de La Timone, Aix-Marseille Université et CNRS, Marseille, 13005, France
Wim Vanduffel
Laboratory for Neuro-and Psychophysiology, Department of Neurosciences, KU Leuven Medical School, Leuven, 3000, Belgium; Leuven Brain Institute, KU Leuven, Leuven, 3000, Belgium; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, United States; Department of Radiology, Harvard Medical School, Boston, MA 02144, United States; Corresponding authors.
Suliann Ben Hamed
Institut des Sciences Cognitives Marc Jeannerod, UMR 5229, Université de Lyon – CNRS, France; Corresponding authors.
Functional localizers are invaluable as they can help define regions of interest, provide cross-study comparisons, and most importantly, allow for the aggregation and meta-analyses of data across studies and laboratories. To achieve these goals within the non-human primate (NHP) imaging community, there is a pressing need for the use of standardized and validated localizers that can be readily implemented across different groups. The goal of this paper is to provide an overview of the value of localizer protocols to imaging research and we describe a number of commonly used or novel localizers within NHPs, and keys to implement them across studies. As has been shown with the aggregation of resting-state imaging data in the original PRIME-DE submissions, we believe that the field is ready to apply the same initiative for task-based functional localizers in NHP imaging. By coming together to collect large datasets across research group, implementing the same functional localizers, and sharing the localizers and data via PRIME-DE, it is now possible to fully test their robustness, selectivity and specificity. To do this, we reviewed a number of common localizers and we created a repository of well-established localizer that are easily accessible and implemented through the PRIME-RE platform.
