Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions

Yingjun Liu; Assunta Senatore; Silvia Sorce; Mario Nuvolone; Jingjing Guo; Zeynep H. Gümüş; Adriano Aguzzi

doi:10.1038/s42003-022-03496-5

Communications Biology (Jun 2022)

Brain aging is faithfully modelled in organotypic brain slices and accelerated by prions

Yingjun Liu,
Assunta Senatore,
Silvia Sorce,
Mario Nuvolone,
Jingjing Guo,
Zeynep H. Gümüş,
Adriano Aguzzi

Affiliations

Yingjun Liu: Institute of Neuropathology, University of Zurich
Assunta Senatore: Institute of Neuropathology, University of Zurich
Silvia Sorce: Institute of Neuropathology, University of Zurich
Mario Nuvolone: Institute of Neuropathology, University of Zurich
Jingjing Guo: Institute of Neuropathology, University of Zurich
Zeynep H. Gümüş: Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai
Adriano Aguzzi: Institute of Neuropathology, University of Zurich

DOI: https://doi.org/10.1038/s42003-022-03496-5
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 11

Abstract

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Cultured brain slices from mice spontaneously upregulate senescence-associated genes over time and reproduce the transcriptional characteristics of aged brains; prions accelerate brain aging in brain slice cultures, animal models and human patients.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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