Nature Communications (Jan 2023)
DNMT3B supports meso-endoderm differentiation from mouse embryonic stem cells
- Andrea Lauria,
- Guohua Meng,
- Valentina Proserpio,
- Stefania Rapelli,
- Mara Maldotti,
- Isabelle Laurence Polignano,
- Francesca Anselmi,
- Danny Incarnato,
- Anna Krepelova,
- Daniela Donna,
- Chiara Levra Levron,
- Giacomo Donati,
- Ivan Molineris,
- Francesco Neri,
- Salvatore Oliviero
Affiliations
- Andrea Lauria
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Guohua Meng
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Valentina Proserpio
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Stefania Rapelli
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Mara Maldotti
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Isabelle Laurence Polignano
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Francesca Anselmi
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Danny Incarnato
- Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute (GBB), University of Groningen
- Anna Krepelova
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Daniela Donna
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Chiara Levra Levron
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Giacomo Donati
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Ivan Molineris
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Francesco Neri
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- Salvatore Oliviero
- Department of Life Sciences and Systems Biology & Molecular Biotechnology Center - MBC, Università di Torino
- DOI
- https://doi.org/10.1038/s41467-023-35938-x
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
DNMT3B-dependent DNA methylation provides epigenetic priming at epiblast stage by methylating enhancers of ectodermal genes to ensure proper differentiation toward mesoendoderm tissues.
