Nature Communications (Dec 2017)

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

  • Matteo Spinelli,
  • Salvatore Fusco,
  • Marco Mainardi,
  • Federico Scala,
  • Francesca Natale,
  • Rosita Lapenta,
  • Andrea Mattera,
  • Marco Rinaudo,
  • Domenica Donatella Li Puma,
  • Cristian Ripoli,
  • Alfonso Grassi,
  • Marcello D’Ascenzo,
  • Claudio Grassi

DOI
https://doi.org/10.1038/s41467-017-02221-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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Metabolic diseases have been associated with cognitive impairment. Here, the authors show that brain insulin resistance induced by high-fat diet leads to increased palmitoylation of AMPA receptors and thus changes in hippocampal plasticity, learning and memory.