Journal of Clinical Medicine (Mar 2023)

CNS Ageing in Health and Neurodegenerative Disorders

  • Evangelia Kesidou,
  • Paschalis Theotokis,
  • Olympia Damianidou,
  • Marina Boziki,
  • Natalia Konstantinidou,
  • Charilaos Taloumtzis,
  • Styliani-Aggeliki Sintila,
  • Panagiotis Grigoriadis,
  • Maria Eleptheria Evangelopoulos,
  • Christos Bakirtzis,
  • Constantina Simeonidou

DOI
https://doi.org/10.3390/jcm12062255
Journal volume & issue
Vol. 12, no. 6
p. 2255

Abstract

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The process of ageing is characteristic of multicellular organisms associated with late stages of the lifecycle and is manifested through a plethora of phenotypes. Its underlying mechanisms are correlated with age-dependent diseases, especially neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and multiple sclerosis (MS) that are accompanied by social and financial difficulties for patients. Over time, people not only become more prone to neurodegeneration but they also lose the ability to trigger pivotal restorative mechanisms. In this review, we attempt to present the already known molecular and cellular hallmarks that characterize ageing in association with their impact on the central nervous system (CNS)’s structure and function intensifying possible preexisting pathogenetic conditions. A thorough and elucidative study of the underlying mechanisms of ageing will be able to contribute further to the development of new therapeutic interventions to effectively treat age-dependent manifestations of neurodegenerative diseases.

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