Research and application progress of gingival mesenchymal stem cells in oral diseases

Abstract

Gingival mesenchymal stem cells(GMSCs)are a population of mesenchymal stem cells found in the lamina propria of gingival tissue and can be isolated not only from healthy gingival tissue but also from hyperplastic or even inflamed gingival tissue. GMSCs have become a hot topic of research in oral disease treatment because of their abundant sources, easy availability, unique immunomodulatory properties and multi-directional differentiation potential. GMSCs have been used in the treatment of periodontitis, gingival recession, oral cancer, mandibular defects, peripheral nerve injury repair and so on. To prevent and treat oral diseases, this study will review the recent progress of research on the application of GMSCs in oral diseases.

Keywords

• |gingival mesenchymal stem cells|tissue engineering|regenerative medicine