Thematic review series: The Pathogenesis of Atherosclerosis. Toward a biological network for atherosclerosis

Anatole Ghazalpour; Sudheer Doss; Xia Yang; Jason Aten; Edward M. Toomey; Atila Van Nas; Susanna Wang; Thomas A. Drake; Aldons J. Lusis

Journal of Lipid Research (Oct 2004)

Thematic review series: The Pathogenesis of Atherosclerosis. Toward a biological network for atherosclerosis

Anatole Ghazalpour,
Sudheer Doss,
Xia Yang,
Jason Aten,
Edward M. Toomey,
Atila Van Nas,
Susanna Wang,
Thomas A. Drake,
Aldons J. Lusis

Affiliations

Anatole Ghazalpour: Department of Human Genetics, Department of Medicine, and Department of Microbiology, Immunology, and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, CA 90095-1679; Department of Biomathematics, University of California, Los Angeles, CA 90095-1766; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095-1732
Sudheer Doss: Department of Human Genetics, Department of Medicine, and Department of Microbiology, Immunology, and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, CA 90095-1679; Department of Biomathematics, University of California, Los Angeles, CA 90095-1766; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095-1732
Xia Yang: Department of Human Genetics, Department of Medicine, and Department of Microbiology, Immunology, and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, CA 90095-1679; Department of Biomathematics, University of California, Los Angeles, CA 90095-1766; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095-1732
Jason Aten: Department of Human Genetics, Department of Medicine, and Department of Microbiology, Immunology, and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, CA 90095-1679; Department of Biomathematics, University of California, Los Angeles, CA 90095-1766; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095-1732
Edward M. Toomey: Department of Human Genetics, Department of Medicine, and Department of Microbiology, Immunology, and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, CA 90095-1679; Department of Biomathematics, University of California, Los Angeles, CA 90095-1766; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095-1732
Atila Van Nas: Department of Human Genetics, Department of Medicine, and Department of Microbiology, Immunology, and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, CA 90095-1679; Department of Biomathematics, University of California, Los Angeles, CA 90095-1766; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095-1732
Susanna Wang: Department of Human Genetics, Department of Medicine, and Department of Microbiology, Immunology, and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, CA 90095-1679; Department of Biomathematics, University of California, Los Angeles, CA 90095-1766; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095-1732
Thomas A. Drake: Department of Human Genetics, Department of Medicine, and Department of Microbiology, Immunology, and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, CA 90095-1679; Department of Biomathematics, University of California, Los Angeles, CA 90095-1766; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095-1732
Aldons J. Lusis: Department of Human Genetics, Department of Medicine, and Department of Microbiology, Immunology, and Molecular Genetics, and Molecular Biology Institute, University of California, Los Angeles, CA 90095-1679; Department of Biomathematics, University of California, Los Angeles, CA 90095-1766; Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095-1732

Journal volume & issue: Vol. 45, no. 10
pp. 1793 – 1805

Abstract

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The goal of systems biology is to define all of the elements present in a given system and to create an interaction network between these components so that the behavior of the system, as a whole and in parts, can be explained under specified conditions. The elements constituting the network that influences the development of atherosclerosis could be genes, pathways, transcript levels, proteins, or physiologic traits..In this review, we discuss how the integration of genetics and technologies such as transcriptomics and proteomics, combined with mathematical modeling, may lead to an understanding of such networks.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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Abstract

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