Rodent Models of Audiogenic Epilepsy: Genetic Aspects, Advantages, Current Problems and Perspectives
David G. Garbuz,
Artem A. Davletshin,
Svetlana A. Litvinova,
Irina B. Fedotova,
Natalya M. Surina,
Inga I. Poletaeva
Affiliations
David G. Garbuz
Laboratory of Molecular Mechanisms of Biological Adaptation, Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia
Artem A. Davletshin
Laboratory of Molecular Mechanisms of Biological Adaptation, Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 119991 Moscow, Russia
Svetlana A. Litvinova
Laboratory of Psychopharmacology of FSBI “Zakusov Institute of Pharmacology”, 125315 Moscow, Russia
Irina B. Fedotova
Chair of Higher Nervous Activity, Biology Department, Lomonosov Moscow State University, 119991 Moscow, Russia
Natalya M. Surina
Chair of Higher Nervous Activity, Biology Department, Lomonosov Moscow State University, 119991 Moscow, Russia
Inga I. Poletaeva
Chair of Higher Nervous Activity, Biology Department, Lomonosov Moscow State University, 119991 Moscow, Russia
Animal models of epilepsy are of great importance in epileptology. They are used to study the mechanisms of epileptogenesis, and search for new genes and regulatory pathways involved in the development of epilepsy as well as screening new antiepileptic drugs. Today, many methods of modeling epilepsy in animals are used, including electroconvulsive, pharmacological in intact animals, and genetic, with the predisposition for spontaneous or refractory epileptic seizures. Due to the simplicity of manipulation and universality, genetic models of audiogenic epilepsy in rodents stand out among this diversity. We tried to combine data on the genetics of audiogenic epilepsy in rodents, the relevance of various models of audiogenic epilepsy to certain epileptic syndromes in humans, and the advantages of using of rodent strains predisposed to audiogenic epilepsy in current epileptology.
