Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery
Satish Rojekar,
Swapnali Parit,
Amol D. Gholap,
Ajit Manchare,
Sopan N. Nangare,
Navnath Hatvate,
Vrashabh V. Sugandhi,
Keshav Raj Paudel,
Rahul G. Ingle
Affiliations
Satish Rojekar
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Swapnali Parit
Institute of Chemical Technology, Marathwada Campus, Jalna 431203, India
Amol D. Gholap
Department of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar 401404, India
Ajit Manchare
Institute of Chemical Technology, Marathwada Campus, Jalna 431203, India
Sopan N. Nangare
Department of Pharmaceutics, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur 425405, India
Navnath Hatvate
Institute of Chemical Technology, Marathwada Campus, Jalna 431203, India
Vrashabh V. Sugandhi
College of Pharmacy & Health Sciences, St. John’s University, 8000 Utopia Parkway, Queens, NY 11439, USA
Keshav Raj Paudel
Centre for Inflammation, School of Life Sciences, Faculty of Science, Centenary Institute and University of Technology Sydney, Sydney, NSW 2007, Australia
Rahul G. Ingle
Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research (Deemed to Be University)—DMIHER, Wardha 442107, India
Microneedle technology revolutionizes ocular drug delivery by addressing challenges in treating ocular diseases. This review explores its potential impact, recent advancements, and clinical uses. This minimally invasive technique offers precise control of drug delivery to the eye, with various microneedle types showing the potential to penetrate barriers in the cornea and sclera, ensuring effective drug delivery. Recent advancements have improved safety and efficacy, offering sustained and controlled drug delivery for conditions like age-related macular degeneration and glaucoma. While promising, challenges such as regulatory barriers and long-term biocompatibility persist. Overcoming these through interdisciplinary research is crucial. Ultimately, microneedle drug delivery presents a revolutionary method with the potential to significantly enhance ocular disease treatment, marking a new era in eye care.
