Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass

Maud Borensztein; Ikuhiro Okamoto; Laurène Syx; Guillaume Guilbaud; Christel Picard; Katia Ancelin; Rafael Galupa; Patricia Diabangouaya; Nicolas Servant; Emmanuel Barillot; Azim Surani; Mitinori Saitou; Chong-Jian Chen; Konstantinos Anastassiadis; Edith Heard

doi:10.1038/s41467-017-01415-5

Nature Communications (Nov 2017)

Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass

Maud Borensztein,
Ikuhiro Okamoto,
Laurène Syx,
Guillaume Guilbaud,
Christel Picard,
Katia Ancelin,
Rafael Galupa,
Patricia Diabangouaya,
Nicolas Servant,
Emmanuel Barillot,
Azim Surani,
Mitinori Saitou,
Chong-Jian Chen,
Konstantinos Anastassiadis,
Edith Heard

Affiliations

Maud Borensztein: Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne
Ikuhiro Okamoto: Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne
Laurène Syx: Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne
Guillaume Guilbaud: Medical Research Council Laboratory of Molecular Biology
Christel Picard: Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne
Katia Ancelin: Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne
Rafael Galupa: Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne
Patricia Diabangouaya: Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne
Nicolas Servant: Institut Curie, PSL Research University, Mines Paris Tech, INSERM U900
Emmanuel Barillot: Institut Curie, PSL Research University, Mines Paris Tech, INSERM U900
Azim Surani: Department of Physiology, Development and Neuroscience, Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge
Mitinori Saitou: Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University
Chong-Jian Chen: Annoroad Gene Technology Co., Ltd
Konstantinos Anastassiadis: Biotechnology Center, Technische Universität Dresden
Edith Heard: Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, UPMC Paris-Sorbonne

DOI: https://doi.org/10.1038/s41467-017-01415-5
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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X-chromosome inactivation is reversed in the mouse inner cell mass (ICM) through a mechanism that is not fully understood. Here, the authors investigate this process and characterize the contributions of the epigenetic landscape and transcription factors in X-linked gene reactivation dynamics.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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